Read e-book online Basic Medical Sciences for MRCP Part 1 PDF

By Philippa J. Easterbrook MB BChir BSc(Hons) FRCP DTM&H MPH

ISBN-10: 0443073260

ISBN-13: 9780443073267

Written for applicants sitting their MRCP half 1 exam, this revision specializes in the ordinary issues which arise within the questions. The booklet additionally contains a bankruptcy on scientific pharmacology (which on my own money owed for as much as 30% of the questions), taking a look at points of drug-induced sickness and drug interactions. ultimately there's a bankruptcy on statistics and epidemiology which is never lined in different texts, yet is frequently integrated within the exam.

  • Helps MRCP half 1 applicants organize for and cross their exam.
  • Addresses an more and more vital subject within the exam.
  • Addresses an issue that's very important to passing the examination, yet which such a lot applicants are poorly ready for.
  • Covers the entire proper easy technology matters plus contains scientific pharmacology.
  • Is of use to applicants learning for different postgraduate checks equivalent to PLAB, USMLE and MRCPCH.
  • Is the 1st e-book of its sort within the club industry and is now considered as crucial for examination preparation.

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Aureus (non-penicillinase-producing strains) Strep. pneumoniae, Strep. viridans and ~-haemolytic strep . Gram -ve cocci N. meningitides and gonorrhoeae Gram +ve bacilli B. anthracis, Cl. tetani Resistant organisms Penicillinase-producing staphylococci Other Strep. faecalis N. gonorrhoeae (some strains) H. coli Klebsiella sp . Proteus sp . Pseudomonas aeruginosa Bacteroides fragifis Mycopfasma pneumonia (lacks a cell wall) .. . mediated) ~-lactamases. 14 (Cont'a) Antibiotic Amoxicillin/ampicillin (penicillinase-sensitive) Monobactams and carbapenems Aztreonam (monobactam) lmipenem (carbapenem) Both contain ~-lactam rings Cephalosporins 1st generation Cefadoxil Cefaloridine Cefalexin Cefradine 2nd generation Cefamandole Cefotoxin Cefuroxime 3rd generation Cefotaxime Ceftriaxone Ceftazidime ...

Li-Fraumeni syndrome (a dominantly inherited monogenic cancer syndrome characterized by breast carcinoma, sarcomas, brain and other tumours). Inactivation of p53 is the primary defect. 2 17q21 13q12-13 11p13 17q12- 22 18q21 MISMATCH REPAIR GENES • Seen in hereditary non-polyposis coli (HNPCC): an autosomal dominant disorder. Associated with the presence of new, rather than loss of, alleles in DNA from tumour tissue. This phenomenon is known as microsatellite instability or replication error. Individuals who inherit a mutation in one of the mismatched repair genes for HNPCC are heterogeneous for a loss of function mutation leading to an increased mutation rate and increased risk of developing malignancy.

Trinucleotide repeats either lie in the 5' non-coding region of genes, where they disrupt gene transcription because they cause steric hindrance of RNA polymerase, or they code for the amino acid glutamine (GAG) and appear to produce a toxic protein which forms intracellular inclusion bodies. G) m z m -I () (J) )> z 0 s: 0 r m () c r )> JJ MOLECULAR BASIS OF SINGLE-GENE DISORDERS Autosomal dominant Achondroplasia Disorder of skeletal development due to mutations in the fibroblast growth factor receptor type 3.

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Basic Medical Sciences for MRCP Part 1 by Philippa J. Easterbrook MB BChir BSc(Hons) FRCP DTM&H MPH

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